저항성 운동이 제2형 당뇨마우스의 인슐린 저항성 및 골격근 IGF-1, BDNF 및 FNDC5 mRNA 발현에 미치는 영향

• 영문명: Effects of Resistance Exercise on Insulin Resistance, IGF-1, BDNF and FNDC5 mRNA Expression of Skeletal Muscle in Tupe 2 Diabetic Mice
• 발행기관: 한국문화융합학회
• 저자명: 강석훈(Suk-Hun Kang)
• 간행물 정보: 『문화와융합』제43권 5호, 909~923쪽, 전체 15쪽
• 주제분류: 복합학 > 학제간연구
• 파일형태: PDF
• 발행일자: 2021.05.30

영문 초록

This experiment investigated the effects of resistance exercise on insulin resistance, iIGF-1), bBDNF) and fibronectin type III domain containing 5FNDC5) mRNA expression in skeletal muscle in type 2 diabetic mice. At 5 weeks of age, C57BL/KsJ-db/db mice (N=36) were randomly assigned to three groups (n=12 in each group): the normal control group (CON), control group with diabetic (DM+Con) and resistance exercise group with diabetic mice(DM+RE). The resistance exercise group showed a significant decrease in h-insulin resistance levels compared to the DM+Congroup (P<.05). IGF-1, BDNF and FNDC5 mRNA expression in skeletal muscle were significantly increased in the resistance exercise group compared to the DM+Congroup (P<.05). Grip strength was significantly increased in the resistance exercise group compared to the DM+Congroup (P<.05). This study suggests that 12 weeks of resistance exercise can induce IGF-1, BDNF and FNDC5 mRNA expression in skeletal muscle and improve insulin resistance in type 2 diabetic mice.

목차

1. 서론

2. 연구방법

3. 결과

4. 논의

5. 결론

키워드

Resistance exercise Insulin resistance Diabetic mice IGF-1 mRNA FNDC5 mRNAnkle