The Study of Overcoming Radiation damage with Chitosan

• 발행기관: 한국방사선학회
• 저자명: Jung hong moon
• 간행물 정보: 『한국방사선학회 학술대회 논문집』한국방사선학회 2017년 추계종합학술대회논문집, 34~34쪽, 전체 1쪽
• 주제분류: 공학 > 기타공학
• 파일형태: PDF
• 발행일자: 2017.11.10

영문 초록

Radiation-therapy causes the adverse radiation effect. It is called osteoradionecrosis. A protein-therapy is carried out in order to cure osteoradionecrosis. The typical method of the protein-therapy is using BMP-2. Considering to bone damage, it is more important that maintains enough to circumstance regeneration for osteoblast differentiation on damage site of bone. Thus, this study is on a tissue regeneration to cure radiation critical damage. I observed that the formation of new ectopic bone and orthopic bone by injection of collagen sheet and Chitosan Beads(BMP-2 : 1μg/ml)) on irradiated mouse. Consequently, I examined new bone formation with only collagen sheet and chitosan Beads on irradiated mouse. Therefore I suggested that using collagen sheet and Chitosan Beads (BMP-2:1μg/ml) )because it can be good for new bone regeneration effect on radiation side effect area. Chitosan and collagen were so effective medicine for new bone regeneration on radiation mouse, moreover adding to BMP-2 offered to synergic effect of bone regenerative environment. In addition to, Containing of two materials in chitosan-particle (BMP-2) and collagen matrix could be suppied to appropriate environment for bone regeneration.

키워드

irradiated mouse BMP-2 osteoradionecrosis