Protective effect of visible red light (660nm) against ultraviolet-induced skin damage

• 발행기관: 한국노년학회
• 저자명: Yeo Jin Kim Hyoung-June Kim Hye Lim Kim Hyo Jeong Kim Hyun Soo Kim Tae Ryong Lee Dong Wook Shin Young Rok Seo
• 간행물 정보: 『한국노년학회 학술대회 논문집』2017년 한국노인과학학술대회, 274~274쪽, 전체 1쪽
• 주제분류: 사회과학 > 사회복지학
• 파일형태: PDF
• 발행일자: 2017.11.03

영문 초록

UV radiation, a major environmental mutagen, is well-known as a major cause of photoaging and skin cancer. Particularly, UVB exposure induces deleterious effects on skin cells, inducing the direct and indirect DNA damage and the generation of reactive oxygen species. In this study, we identified the protective effect of visible red light against UVB exposure in normal human dermal fibroblasts in terms of the generation of oxidative stress and DNA stands breaks. Using gamma-H2AX assay and comet assay, we identified that visible red light is safer than blue light on DNA damage induction in NHDFs. Furthermore, in both two- and three-dimensional cell culture systems we also identified that pre- and post-treatment of visible red light reduces UVB-induced DNA damage. Present results provides elucidation of the photo-protective effect of visible red light against UV-induced skin damage. Furthermore, our study suggests key clues in application of visible red light for development of aging-related skin care system.

키워드

Visible red light Protective effect DNA damage