Analysis of Survival Data with Cure Rate using Frailty

• 발행기관: 한국자료분석학회
• 저자명: 하일도(Il Do Ha)
• 간행물 정보: 『Journal of The Korean Data Analysis Society (JKDAS)』Vol.7 No.6, 1915~1923쪽, 전체 9쪽
• 주제분류: 자연과학 > 통계학
• 파일형태: PDF
• 발행일자: 2005.12.30

영문 초록

The study about cure rate is an important issue in clinical trials for diseases such as cancer. For this the cure survival models have been often used. However, there can be a heterogeneity in risk for survival data with cure rate. Such heterogeneity can be modelled by introducing a frailty term in the cure models. We present how to model the cure rate via frailty and to fit the models using SAS PROC NLMIXED. The proposed method is illustrated with recurrence data from a clinical trial on leukemia patients. In particular, we demonstrate that the allowance of frailty in cure models can be identified using the procedures of testing and model selection.

목차

1. Introduction

2. Modelling Cure Rate

3. Application

4. Discussion

References

키워드

Cure models Cure rate Frailty models Model selection