Anti-inflammatory Activity of Cone from Red Pine (Pinus densiflora)

• 영문명: Anti-inflammatory Activity of Cone from Red Pine (Pinus densiflora)
• 발행기관: 한국자원식물학회
• 저자명: Choi, Ji-Soo Sung, Ji-Ho Jang, Tae-Won Mun, Jeong-Yun Im, Jong-Yun Park, Jae-Ho
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2019년도 춘계학술대회, 119~119쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

Allergic inflammatory disease has been increased by abnormal lifestyle and food habits. Especially, prevalence of atopic dermatitis (AD) has been elevated and treatment of AD has not been unclear. Red sweet pepper (RSP), named as Capsicum annuum L, has been known as having pharmacological effects such as antioxidant, detoxification and antibacterial effects. However, the beneficial effect of ethanolic extract of RSP on AD has not been partly examined yet. Therefore, the aim of this study was to investigate anti-inflammatory effects of RSP on AD in vitro and in vivo models. The treatment of RSP inhibited the secretion of inflammatory cytokine such as interleukin (IL)-6 and IL-8 in tumor necrosis factor (TNF)-${\alpha}$ and interferon (IFN)-${\gamma}$-stimulated human keratinocyte (HaCaT cell). Also, RSP extract regulated 2,4-dinitroflorobenzene (DNFB)-induced AD-like skin lesions in BALB/c mice. Oral administration of RSP ameliorated DNFB-induced AD-like symptoms. In presented results indicated that RSP inhibited inflammatory cytokines in HaCaT cell and ameliorated AD-like skin lesion through suppression of symptom of DNFB-induced skin inflammation. Thus, RSP might be a potential therapeutic agent for AD.

키워드

Red sweet pepper inflammation cytokine HaCaT cell 2,4-dinitrofluorobenzene