1-MCP(1-Methylcyclopropene) 훈증 처리가 절화 백합 '시베리아'와 '메두사'의 잎 황화와 절화 수명에 미치는 영향

• 영문명: Effect of 1-MCP Fumigation on the Leaf Chlorosis and Vase Life of Cut Lilies 'Siberia' and 'Medusa'
• 발행기관: 한국자원식물학회
• 저자명: 최지원(Choi, Ji-Weon) 이지현(Lee, Ji-Hyun) 이정수(Lee, Jung Soo) 강윤임(Kang, Yun-Im) 신일섭(Shin, Il Sheob)
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2019년도 춘계학술대회, 91~91쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

In this study, we evaluated the effect of branch (STB) and leave (STL) extracts from Sageretia thea on ${\beta}$-catenin level in human colorecal cancer cells, SW480 and lung cancer cells, A549. STB and STL dose-dependently suppressed the growth of SW480 and A549 cells. STB and STL decreased ${\beta}$-catenin level in both protein and mRNA level. MG132 decreased the downregulation of ${\beta}$-catenin protein level induced by STB and STL. However, the inhibition of $GSK3{\beta}$ by LiCl or ROS scavenging by NAC did not block the reduction of ${\beta}$-catenin protein by STB and STL. Our results suggested that STB and STL may downregulate ${\beta}$-catenin protein level independent on $GSK3{\beta}$ and ROS. Based on these findings, STB and STL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer and lung cancer.

키워드

Anticancer activity ${\beta}$-catenin Cancer chemoprevention Sageretia thea