인체 방광암 T24 세포에서 Glycyrrhizae radix 열수추출물에 의한 apoptosis 유도

• 영문명: Induction of apoptosis by water extract Glycyrrhizae radix in human bladder T24 cancer cells
• 발행기관: 한국자원식물학회
• 저자명: 엄정혜(Eom, Jung Hye) 황병수(Hwang, Buyng Su) 정용태(Jeong, Yong Tae) 김민진(Kim, Min-Jin) 신수영(Shin, Su Young) 김철환(Kim, Chul Hwan) 이승영(Lee, Seung Young) 최경민(Choi, Kyung Min) 조표연(Cho, Pyo Yun) 정진우(Jeong, Jin-Woo) 오영택(Oh, Young Taek)
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2019년도 춘계학술대회, 111~111쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

Baicalein is one of the main flavonoids derived from roots of Scutellaria baicalensis Georgi, a traditional Oriental medicine. Although baicalein has high antitumor effect on several human carcinomas, the mechanism responsible for this property is not unclear. In this study, the data revealed that baicale-ininduced growth inhibition was associated with the induction of apoptosis connecting with cytochrome c release, down-regulation of anti-apoptotic Bcl-xl and increased the percentage of cells with a loss of mitochondria membrane permeabilization. Baicalein also induced the proteolytic activation of caspases and cleavage of PARP; however, blockage of caspases activation by z-VAD-fmk inhibited baicalein-induced apoptosis. In addition, baicalein enhanced the formation of autophagosomes and up-regulated LC3-II/LC3-I ratio. Interestingly, the pretreatment of bafilomycin A1 recovered baicalein-induced cell death suggesting that autophagy by baicalein roles as protective autophagy. Taken together, our results indicated that this flavonoid induces apoptosis and cell protective autophagy. These data means combination treatment with baicalein and autophagy inhibitor might be a promising anticancer drug.