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학술논문

Anticancer Activity of Taxillus yadoriki Parasitic to Neolitsea sericea against Non-Small Cell Lung Carcinoma

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Anticancer Activity of Taxillus yadoriki Parasitic to Neolitsea sericea against Non-Small Cell Lung Carcinoma
발행기관
한국자원식물학회
저자명
Park, Su Bin Kim, Ha Na Kim, Jeong Dong Jeong, Jin Boo
간행물 정보
『한국자원식물학회 학술심포지엄』2019년도 춘계학술대회, 93~93쪽, 전체 1쪽
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농수해양 > 기타농수해양
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2019.04.30
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In this study, we elucidated the anti-inflammatory mechanisms of leaves extracts from Rodgersia podophylla (RPL) in RAW264.7 cells. RP-L significantly inhibited the production of the proinflammatory mediators such as NO, iNOS, IL-$1{\beta}$ and IL-6 in LPS-stimulated RAW264.7 cells. RPL increased HO-1 expression in RAW264.7 cells, and the inhibition of HO-1 by ZnPP reduced the inhibitory effect of RPL against LPS-induced NO production in RAW264.7 cells. Inhibition of p38, ROS and $GSK3{\beta}$ attenuated RPL-mediated HO-1 expression. Inhibition of ROS inhibited p38 phosphorylation and $GSK3{\beta}$ expression induced by RPL. In addition, inhibition of $GSK3{\beta}$ blocked RPL-mediated p38 phosphorylation. RPL induced nuclear accumulation of Nrf2, and Inhibition of p38, ROS and $GSK3{\beta}$ abolished RPL-mediated nuclear accumulation of Nrf2. Furthermore, RPL blocked LPS-induced degradation of $I{\kappa}B-{\alpha}$ and nuclear accumulation of p65. RP-L also attenuated LPS-induced phosphorylation of ERK1/2 and p38. Our results suggest that RPL exerts potential antiinflammatory activity by activating ROS/$GSK3{\beta}$/p38/Nrf2/HO-1 signaling and inhibiting NF-${\kappa}B$ and MAPK signaling in RAW264.7 cells. These findings suggest that RPL may have great potential for the development of anti-inflammatory drug.

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APA

Park, Su Bin,Kim, Ha Na,Kim, Jeong Dong,Jeong, Jin Boo,. (2019).Anticancer Activity of Taxillus yadoriki Parasitic to Neolitsea sericea against Non-Small Cell Lung Carcinoma. 한국자원식물학회 학술심포지엄, 2019 (1), 93-93

MLA

Park, Su Bin,Kim, Ha Na,Kim, Jeong Dong,Jeong, Jin Boo,. "Anticancer Activity of Taxillus yadoriki Parasitic to Neolitsea sericea against Non-Small Cell Lung Carcinoma." 한국자원식물학회 학술심포지엄, 2019.1(2019): 93-93

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