설파살라진의 항알레르기 효과

• 영문명: Antiallergic Effect of Sulfasalazine
• 발행기관: 대한약학회
• 저자명: 김형민(Hyung Min Kim) 신태용(Tae Yong Shin)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 652~657쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

We studied the effects of sulfasalazine(SSZ) on anaphylaxis. SSZ was found to exhibit a inhibitory activity on the compound 48/80-induced anaphylaxis. SSZ also inhibited local anaphylaxis activated by anti-dinitrophenyl(DNP) IgE. Moreover, SSZ dose-dependently inhibited histamine ralease in rat peritoneal mast cells activated by compound 48/80 or anti DNP IgE. We investigated the effects of SSZ on cAMP of rat peritoneal mast cell. The level of cAMP in rat peritoneal mast cells, when SSZ was added, transiently and significantly increased approximately 16-fold compared with that of basal cells. These results suggest that the antianaphylactic action of SSZ may be associated with an increase in the intracellular cAMP content of the mast cells as the result of an inhibition of the cAMP phosphodiesterase.

키워드

Sulfasalazine Anaphylaxis Compound 48/80 Anti-dinitrophenyl(DNP)IgE cAMP Histamine Mast cells.