질산치아민의 제조조건과 치아민 모노염류의 제제학적 안정성

• 영문명: Synthesis Conditions of Thiamine Mononitrate and Pharmaceutical Stability of Thiamine Monosalts
• 발행기관: 대한약학회
• 저자명: 박홍구(Hong Koo Park)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 595~601쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

The optimal synthesis condition based on the yield of thiamine mononitrate has been attained according to Box-wilson experimental design. The optimal condition was as follows : Molar concentration ratio of SB1.HCL=0.6839, quantity of NH4NO3=50.09g, agitation velocity=51.6rpm, reaction temperature=22.8oC. The stabilities of three kinds of thiamine monosalts(thiamine monoiodide, -monobromide, -monorhodanate) were investigated in sterile solution, compressed tablet and multivitamin capsule, respectively. Assay data are given to show that thiamine monosalts are not significantly higher than that of thiamine mononitrate in sterile solutions and the addition of an acidic stabilizer is unnecessary. The solutions were clear and free of precipitate and didn't discolored after storage at room temperature and 40oC for 6 months. The tablets and capsules were assayed initially and at predetermined intervals during storage at room temperature and 40oC for 6 months. Thiamine monorhodanate was found to be more stable than other thiamine monosalts in these compressed tablets containing other vitamin of the B complex and the data indicate that thiamine monosalts was similar to that of thiamine mononitrate in the multivitamine capsules.

키워드

Thiamine mononitrate pharmaceutical stability thiamine monorhodanate.