플루비프로펜 및 플루비프로펜 악세틸이 함유된 마이크로에멀젼의 제조 및 평가

• 영문명: Preparation and Evaluation of Flurbiprofen- and Flurbiprofen Axetil-loaded Microemulsion
• 발행기관: 대한약학회
• 저자명: 신광현(Kwang Hyun Shin) 황성주(Sung Joo Hwang) 박경미(Kyung Mi Park) 김종국(Chong Kook Kim)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 607~614쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

Flurbiprofen- and flurbiprofen axetil-loaded microemulsions composed of soybean oil, poloxamer 407, glycerine and water were prepared by generator-type homgenizer and ultrasonic probe system. The particle size of microemulsions was measured by the dynamic light scattering method. The pharmacokinetics and organ distribution of flurbiprofen were investigated after intravenous injection of flurbiprofen solution, flurbiprofen-loaded microemulsion and flurbiprofen axetil-loaded microemulsions equivalent to 10mg/kg of flurbiprofen to rats. Blood samples were collected from the anterior ciliary artery of rats for 24hr, and flurbiprofen in plasma and organs was analyzed by HPLC. Stable microemulsions were prepared. Even though there is a little change in droplet size just after the preparation, no creaming and no separation were occured during the storage period for 6 months at 4, 21, 37 and 45oC. Pharmacokinetic parameters and organ distribution of flurbiprofen after intravenous injection of flurbiprofen- and flurbiprofen axetil-loaded microemulsions emulsified with poloxamer 407 were not significantly different from those of commercial lipid microemulsion emulsified with lecithin. Therefore, it is concluded that flurbiprofen- and flurbiprofen axetil-loaded microemulsion prepared with poloxamer 407 could be used as a parenteral formulation.

키워드

Flurbiprofen Flurbiprofen axetil Poloxamer 407 Microemulsion Parenteral formulation.