천연물로부터 염증성 포스포리파제 A2 저해제 검색

• 영문명: Screening of Inflammatory Phospholipase A2 Inhibitors from Natural Products
• 발행기관: 대한약학회
• 저자명: 문태철(Tae Chul Moon) 정광원(Kwang Won Chung) 정규찬(Kyu Charn Chung) 손건호(Kun Ho Son) 김현표(Hyun Pyo Kim) 강삼식(Sam Sik Kang) 장현욱(Hyeun Wook Chang)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 565~570쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

High levels of extracellular phospholipase A2 (Plase A2) associated with inflammatory process in man and animal models have been extensively reported elsewhere. Thus, a logical approach to the treatment of inflammatory diseases should involve the inhibitors of Plase A2. To develop new Plase A2 inhibitors from natural products, two hundred crude drugs were screened using group II PLA2 inhibitory activity. Among them, methanol extract of 5 medicinal plants such as, Raphani Semen, Moutan cortex radicis, Arecae semen, Caryophylli Cortex and Betulae Cortex inhibited more than 90% of PLase A2 activity at a concentration 2.5mcg/ml. Then, 10 methanol extracts sample were transferred into organic solvents, PLase A2 inhibitory effects were found mainly in CHCl3 and EtoAc fractions.

키워드

Inflammation Group Ⅱ Phospholipase A2 inhibitor Natural products.