1N-아릴-2-메틸-3-에톡시카르보닐-피리디노 [2,3-f]인돌-4,9-디온 유도체의 합성 (II)

• 영문명: Synthesis of 1N-aryl-2-methyl-3-ethoxycarbonyl-pyridino [2,3-f]indole-4,9-dione derivatives (II)
• 발행기관: 대한약학회
• 저자명: 서명은(Myung Eun Suh) 박희경(Hee Kyung Park)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 582~587쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

The 6.7-dichloroquinoline-5,8-dione (I) was reacted with ethyl acetoacetate in the presence of sodium ethoxide to yield 6-(alpha-acetyl-alpha-ethoxycarbonyl methyl)-7-chloro-quinoline-5,8-dione(II). When this compound II was reacted with some arylamine (phenyl, p-toluyl, p-fluorophenyl, p-chlorophenyl. p-bromophenyl, p-iodophenyl, p-trifluoromethylphenyl, p-dimethylaminophenyl,indanyl), 1N-aryl-2-methyl-3-ethoxycarbonyl pyridino[2,3-f]-indole-4.9-dione(IIIa-I) were obtained via intramolecular cyclization

키워드

6.7-dichloroquinoline-5.8-dione 6-(a-acetyl-a-ethoxycaibonyl methyl)-7-chloro-quinoline-5.8-dione 1N-phenyl-2-methyl-3-ethoxycarbonyl pyridino[2.3-f]indole-4.9-dione 1N-pdimethylaminophenyl- 2-methyl-3-ethoxycarbonyl pyridino[2.3-flindole-4.9-dione 1N-p-fluoro-phenyl-2-methyI-3-ethoxycarbonyl pyridino[2.3-f]indole-4.9-dione.