치오포스포티로신을 함유한 펩티드 유도체의 중간체 합성

• 영문명: Synthesis of the Key Intermediate for the Preparation of Thiophosphotyrosine-containing Peptide Derivatives
• 발행기관: 대한약학회
• 저자명: 김은경(Eun Kyung Kim) 최희성(Hee Sung Choi) 이응석(Eung Seok Lee)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 588~594쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

N-(tert-Butoxycarbonyl)-omicron-(dicyanoethylthiophosphono)-L-tyrosine(7), the key intermediate for the synthesis of thiophosphotyrosine-containing peptide derivatives, was prepared. For the phosphorylation, we used tau-Boc-tyrosine and phosphoramidite in the presence of 1H-tetrazol. For the protection of thiophosphate moiety, cyanoethyl protecting group was used. Thiophosphotyrosine-containing peptides could be used as tools for the elucidation of mechanism of signal transduction pathway and also prepared as PTK inhibitors, PTPase inhibitors and cytosolic protein binding blockers. It may be contributed for the development of potential anticancer agents.

키워드

thiophosphotyrosine peptide synthesis phosphorylation signal transduction pathway.