1N-알킬-2-아미노-3-에톡시카르보닐-피리디노 [2,3-f]인돌-4,9-디온 유도체의 합성 (I)

• 영문명: Synthesis of 1N-alkyl-2-amino-3-ethoxycarbonyl-pyridino [2,3-f]indole-4,9-dione derivatives (I)
• 발행기관: 대한약학회
• 저자명: 서명은(Myung Eun Suh) 신성희(Sung Hee Shin)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 575~581쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

The 6,7-dichlorquinoline-5,8-dione was reacted with alpha-cyanoacetic acid ethyl ester in ammonia solution to yield 6-(alpha-cyano-alpha-ethoxycarbonyhnethyl)-7-chloroquinoline-5,8-dione (compound I). When this compound was reacted with some alkyl amines (methylamine, ethylamine, isopropylamine, etc) 2-amino-3-ethoxycarbonyl-N-alkyl-pyridino[2,3-f]indole-4,9-diones (compounds II a-e) were obtained.

키워드

6.7-dicMorquinoline-5.8-dione α-cyanoacetic acid ethyl ester 6-(α-cyano-α-ethoxycarbonylmethyl)-7-chloroquinoline-5,8-dione 2-amino-3-thoxycarbonyI-N-alkyhpyridino[2.3-f]indole-4,9-diones.