산오리나무의 세포독성 성분연구

• 영문명: Studies on the Cytotoxic Constituent of Alnus hirsuta(SPACH) RUPR.
• 발행기관: 대한약학회
• 저자명: 배춘일(Choon Il Bae) 공재명(Jae Myung Gong) 오정완(Jung Wan Oh) 김현종(Hyun Jong Kim) 오갑진(Gab Jin Oh) 박시경(Si Kyung Park) 정순간(Sun Gan Chung) 조의환(Eui Hwan Cho)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 559~564쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

To find out antitumor active principles from natural resources, we have evaluated various extracts from the leaves of Alnus hirsuta (Betulaceae). The ethylacetate extract of this plant was found to show a significant cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A5 49, HCT15, SKOV3, HEP3B) in vitro. Using cytotoxicity-guided chromatographic purification of the ethylacetate extract, cytotoxic constituent:1,7-bis-(4-hydroxyphenyl)-5-(beta-D-glucopyranosyloxy)-3-heptanone, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.

키워드

Alnus hirsuta Betulaceae cytotoxic effect 1.7-bis-(4-hydoxyphenyl)-5-(β-D-glucopyranosyloxy)-3-heptanone(platyphylloside) diaryIheptanoid.