팔방산호충류에서 분리한 해양 스테롤 화합물의 혈소판 응집 억제작용

• 영문명: Inhibition of Platelet Activation by Marine Sterols from Octocorals
• 발행기관: 대한약학회
• 저자명: 박영현(Young Hyun Park) 장성근(Sung Keun Chang) 서영완(Young Wan Seo) 신종헌(Jong Heon Shin)
• 간행물 정보: 『약학회지』제41권 제5호 (1997년), 547~553쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.10.31

영문 초록

The purpose of this investigation was to determine the inhibition on Na+, K+-ATPase, cyclic AMP phosphodiesterase and platelet activation by marine sterols isolated from octocorals. Three marine polyhydroxysterols, 7alpha, 8alpha-epoxy-3beta, 5alpha, 6alpha-trihydroxycholestane (1), 24-methyl-7alpha, 8alpha-epoxy-3beta, 5alpha, 6alpha-trihydroxycholest-22-ene (2). and 7alpha, 8alpha-epoxy-3beta, 5alpha. 6alpha-trihydroxycholest-22-ene (3), were isolated from the Gorgonian Acabaria undulata. Five marine sterols(compound 4, 5, 6, 7, 8) were isolated from the soft coral Alcyonium gracillimum. Three marine polyhydroxysterols (1, 2, 3) and pregna-1. 20-diene-3-one (8) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by collagen and thrombin. Those polyhydroxysterols also exhibit a potent inhibitory effect on cyclic AMP phosphodiesterase. Compound 6 with an unusual cyclic enolether exhibit a inhibitory effect on Na+, K+-ATPase.

키워드

Marine sterols Platelet aggregation Na+ K+-ATPase cyclic AMP phosphodiesterase.