IMPROVED STABILITY AND IN VITRO SKIN PERMEATION OF ELASTIC LIPOSOMES LOADED WITH MAACKIA AMURENSIS EXTRACT

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: In Ki HONG Ah Hyeon KIM Sang keun HAN Hak hee KANG Soo Nam PARK
• 간행물 정보: 『한국유화학회 학술대회 논문집』2017년 추계학술대회, 38~38쪽, 전체 1쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2017.11.02

영문 초록

In this study, We prepared elastic liposome containing Maackia amurensis extract, Known as skin whitening effect, evaluated the vesicles size, elasticity, loading efficiency, stability, and in vitro skin permeation. Elastic liposome consisted of sodium-cholate and lyso-phospholipids (edge activator) was prepared in order to supplement stability defect of the conventional elastic liposome. In general, conventional elastic liposome are unstable. Lsophospholipids, sodium-cholate, cholesterol, diacylglycerols, and Tween80 were tested as edge activators. Of the edge activators, Sodium-cholate and lysophospholipids resulted more stable than did normally edge activators. The mean diameter of Maackia amurensis extract loaded elastic liposome formulation ranged between 150 ~ 250nm and loading efficiency was observed 65.5~81.8%. The hightest loading efficiency (81.8%) and deformability (25.6) were observed at the optimal ratio of 85 : 10 : 5(phospholipids : sodium-cholate : lyso-phospholipids) among 0.1% Maackia amurensis extract loaded elastic liposome formulation. Elastic liposome formulation was selected for further transdermal permeation study. Advance elastic liposome exhibited more skin permability than general liposome. These results suggest that elastic liposome formulation using sodium-cholate and lyso-phospholipids as a major edge activator could be useful for the delivery of active ingredient through the skin transdermal and improved stability of elastic liposome.