글리시르히진이 생쥐에 이식된 L1210 세포의 아포프토시스에 미치는 영향

• 영문명: Effect of Glycyrrhizin on Apoptosis of Transplanted-Ll2lO cells in mice
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 권진(Jin Kwon) 오찬호(Chan Ho Oh)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 324~329쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

These experiments were conducted to investigate effects of glycyrrhizin (GL) on apoptosis of transplanted-L1210 cells in mice. GL induced apoptosis of transplanted-Ll2lO cells. GL increased nitric oxide production from peritoneal macrophages of L1210 cells-transplanted mice. NOC12, nitric oxide donor, induced apoptosis of L1210 cells in vitro. The apoptosis of L1210 cells were enhanced by co-culture of the peritoneal macrophages of GL-administered mice and L1210 cells in vitro, and was inhibited by L-NMMA. These results suggest that the apoptosis of transplanted-Ll2lO cells is partly induced by nitric oxide produced from peritoneal macrophages in GL-administered mice.

키워드

Glycyrrhizin Apoptosis Macrophage Nitric oxide.