영지버섯 생장점 단백다당체 GLB의 대식세포 활성화 효과

• 영문명: Activation of Macrophages by GLB, a Protein-polysaccharide of the Growing Tips of Ganoderma Lucidum
• 발행기관: 대한약학회
• 저자명: 오정연(Jung Yeon Oh) 조경주(kyung Joo Cho) 정수현(Soo Hyun Chung) 김진향(Jin Hyang Kim) Hyun S. Lillehoj 정경수(Kyeong Soo Chung)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 302~306쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

In the previous study we described the antitumor activity of GLB, a protein-polysaccharide fraction of the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study we investigated the stimulatory activity of GLB on macrophages. When analyzed using a flow cytometer, GLB (100mcg/ml) was found to increase the phagocytic activity of the BALB/c mouse peritoneal macrophages as well as chicken macrophage BM2CL cells against FITC-labeled C.albicans by 55.2% and 21.2%, respectively. GLB also increased the spreading and the expression of MHC class II molecules of BM2CL cells as well as the mouse peritoneal macrophages. From these results, it is clear that GLB is a strong stimulator to the macrophages.

키워드

Ganoderma lucidum GLB immunomodulator macrophage phagocytic activity Candida albicans.