선퇴에 의한 즉시형 알레르기 반응의 억제

• 영문명: Inhibition of Immediate Allergic Reaction by Cryptotympana atrata
• 발행기관: 대한약학회
• 저자명: 신태용(Tae Yong Shin) 김성화(Seong Hwa Kim) 김형민(Hyung Min Kim)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 319~323쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

Effects of the aqueous extract of Cryptotympana atrata Fabricius (CAF) on the allergic reactions were investigated. In the present study, we examined the effect of CAF on compound 48/80-induced anaphylaxis in vivo and histamine release from rat peritoneal mast cells in vitro. CAF dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. CAF significantly inhibited serum histamine levels induced by compound 48/80. CAF also inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80. These results suggest that CAF may be useful for the prevention and treatment of allergy related disease.

키워드

Cryptotympana atrata Anaphylaxis Compound 48/80 Histamine Mast cells.