참소리쟁이의 세포독성 성분

• 영문명: Cytotoxic Constituents of Rumex japonicus
• 발행기관: 대한약학회
• 저자명: 김대근(Dae Keun Kim) 최상운(Sang Un Choi) 류시용(Si Yong Ryu) 이강노(Kang Ro Lee) 지옥표(Ok Pyo Zee)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 233~237쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compounds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with ED50 values ranging from 2.68 to 10.06mcg/ml.

키워드

Rumex japonicus cytotoxicity musizin emodin.