인삼 사포닌류가 종양괴사인자의 생성 및 T 세포 증식에 미치는 효과

• 영문명: Effect of Ginsenosides from Panax Ginseng on TNF-alpha Production and T Cell Proliferation
• 발행기관: 대한약학회
• 저자명: 조재열(Jae Youl Cho) 박지수(Ji Soo Park) 유은숙(Eun Sook Yoo) 백경업(Kyong Up Baik) 박명환(Myung Hwan Park) 한병훈(Byung Hoon Han)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 296~301쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

To investigate the effects of ginsenosides from Panax ginseng on mitogenic responses in macrophages and splenocytes from murine, we examined the effects of representative protopanaxadiol and protopanaxatriol ginsenosides (Rb1, Rb2, Re and Rg1) on tumor necrosis factor-alpha (TNF-(alpha) production in and smurine macrophage cell line (RAW264.7 cells) stimulated by lipopolysaccharide (LPS) and T cell proliferation in splenocytes stimulated by concanavalin A (Con A). Among the ginsenosides tested, protopanaxadiol ginsenosides (Rb1 and Rb2) significantly inhibited TNF-alpha production in a dose-dependent manner. However, protoppanaxatriol ginsenosides (Re and Rg1) showed little inhibitory activity. The molar concentrations of Rb1 and Rb2 producing 50% inhibition (IC50) of TNF-alpha production were 55.8mcg/ml (48.0mcM) and 31.8mcg/ml (27.9mcM), respectively. As a positive control, prednisolone also exhibited inhibitory activity with an IC50 value of 21.7mcM. In T cell proliferation, Rg1, was not effective but Rb1 and Re or Rb2 significantly increased or inhibited at high concentration, 75 and 100mcg/ml. In contrast, prednisolone showed potent inhibitory activity with an IC50 value of 6.1nM. These results suggest that ginsenosides may take part in the mitogen-induced signaling pathway for TNF-alpha production and T cell proliferation from macrophages splenocytes.

키워드

Ginsenosides TOF-α T cell proliferation mitogenic response.