포공령의 카드뮴에 대한 세포독성 억제효과

• 영문명: The Inhibitory Effects of Taraxaci Herba against Cadmium induced Cytotoxicity
• 발행기관: 대한약학회
• 저자명: 한두석(Du Seok Han) 이기남(Ki Nam Lee) 이종섭(Jong Sub Lee) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 307~311쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

This study was carried out to evaluate antitoxic effects Taraxaci Herba extract against Cadium by calorimetric methods. The antitoxic activity of Taraxaci Herba extract in NIH 3T3 fibroblasts was evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-phenyl-2H-tetrazoliumbromide), NR (Neutral red) and SRB (Sulforhodamine B protein) assay. The light microscopic study was carried out to observe morphological changes of the treated cells. These results were obtained as follows; The concentration of 10-2mg/ml of Taraxaci Herba extract was shown significant antitoxic activity. The number of NIH 3T3 fibroblasts were antitoxic and tend to regenerate. These results suggest that Taraxaci Herba extract retains a potential antitoxic activity.

키워드

Taraxaci Herba extract MTT assay NR assay SRB assay colorimetric method antitoxic activity.