삼백초의 진통성분

• 영문명: Analgesic Constituent from the Herba of Saururus chinensis (LOUR.) BAILL.
• 발행기관: 대한약학회
• 저자명: 박시경(Si Kyung Park) 오갑진(Gab Jin Oh) 김현태(Hyun Tae Kim) 김현종(Hyun Jong Kim) 정순간(Sun Gan Chung) 조의환(Eui Hwan Cho)
• 간행물 정보: 『약학회지』제42권 제3호 (1998년), 238~242쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.06.30

영문 초록

For the investigation of bioactive natural products with analgesic activity, we have evaluated various extracts of Saururi Herba (Saururaceae), which has been used in traditional medicine for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The diethylether extract of this plant was found to show a significant analgesic effect on writhing syndrome in mice. Using bioactivity-guided separation of the diethylether extract, analgesic constituent, (8S, 8`R, 7R, 6`R)-2`-oxo-4,5: 4`,5`-bis(methylenedioxy)-delta1,3,5,3`-8.8`, 7.6`, 2.O.5`-neolignan(sauchinone) was isolated and structurally identified by physico-chemical properties and spectroscopic evidences. This compound has good analgesic activity with lower toxicity, as compared to other antipyretic-analgesic drug(acetaminophen).

키워드

Saururus chinensis (LOUR.) BAILL Saururaceae analgesic effect (8S, 8`R, 7R, 6`R)-2`-oxo-4,5: 4`,5`-bis(methylenedioxy)-delta1,3,5,3`-8.8` 7.6`,2.O.5`-neolignan(sauchinone) lignan.