MLS계 항생제에 대한 유도내성 유전자 ermK 및 그 돌연변이체의 유도내성 표현형

• 영문명: Characteristics of the Resistance Phenotypes by Inducible Resistance Gene ermk and Its Terminator Region Mutants
• 발행기관: 대한약학회
• 저자명: 최성숙(Sung Sook Choi) 최응칠(Eung Chil Choi)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 533~537쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

The characteristics of the resistance phenotypes of Bacillus subtilis having ermk and its terminator region mutants were determined. Wild type ermK(pEC101) and pECMT109(methylase SD-region mutant) showed typical inducible resistance phenotype. pECMF1(terminator1 region mutant) and pECMT2(terminator2 region mutant) showed constitutive resistance to Kitasamycin but inducible resistance to tylosin. In contrast, pECMT3(terminator1 and terminator2 double mutant) and pECMT309(terminator1, terminator2 and methylase SD region triple mutant) showed constitutive resistance both to kitasamycin and tylosin.

키워드

Resistance MLS antibiotics ermK Phenotypes.