수종 생약의 티로시나제 억제효과

• 영문명: Tyrosinase Inhibition Activity of Some Herbal Drugs
• 발행기관: 대한약학회
• 저자명: 박정일(Jeong Hill Park) 신영근(Young Geun Shin) 신언경(Un Kyung Shin) 백선경(Sun Kyung Baek) 이승기(Seung Ki Lee) 정명희(Myung Hee Chung) 박영인(Young In Park)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 518~523쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

To isolate biologically active compounds which exhibit tyrosinase inhibition activity and ultimately express skin whitening effect, 14 oriental herbal drugs were screened in terms of tyrosinase inhibition. For this purpose, in vitro enzyme assay system for tyrosinase, so called Pomerantz method with some modifications has been established. Crude methanolic extracts from 14 herbal drugs were made and examined for their inhibitory activity against tyrosinase. Those extracts fromCnidii Rhizoma, Arecae Semen, Caryophylli Flos, and Ephedrae Herba showed strong inhibitory activities on mushroom tyrosinase. Therefore, crude methanolic extracts from those 4 herbal drugs were further fractionated using ether, butanol and water. respectively. The ether and n-butanol extracts from Arecae Semen and the n-butanol and water extracts from Caryophylli Flos, respectively, showed relatively strong tyrosinase inhibitory activity compared to arbutin.

키워드

Whitening effect tyrosinase inhibition herbal drugs.