고등식물로부터 피부멜라닌 생성에 관여하는 티로시나제 활성 억제물질의 탐색

• 영문명: The Screening of the Inhibitory Compounds on Tyrosinase Activity from the Natural Product
• 발행기관: 대한약학회
• 저자명: 이승호(Seung Ho Lee) 박지수(Ji Soo Park) 김소영(So Young Kim) 김진준(Jin Joon Kim) 정시련(See Ryun Chung)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 456~461쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

Tyrosinase is known to accelerate the melanin polymer biosynthesis in melanocyte, so tyrosinase inhibitors hinder the melanin polymer biosynthesis and are useful not only for the material used in cosmetics as skin-whitening agents but also as the remedy for disturbances in pigmentation. During our search for new melanin biosynthesis inhibitors from natural sources, 130 higher plants were tested for the inhibitory effect against tyrosinase activity by the mushroom tyrosinase assay. Among them, Carex humilis (IC50, 10vg/ml), Sophora flavescence (IC50, 20~50mcg/ml) and Styrax japonica (IC50, 10mcg/ml) inhibited the tyrosinase activity strongly.

키워드

Tyrosinase inhibitor melaninpolymer pigmentation Carex humilis Sophora flavescence Styrax japonica