콜레스테롤과 비타민 D2 첨가 사료로 유도된 흰쥐의 고지혈증에 대한 Taurine의 효과

• 영문명: Effect of Taurine on Hyperlipidemic Rats Fed Cholesterol and Vitamin D2 containing Diet
• 발행기관: 대한약학회
• 저자명: 이은방(Eun Bang Lee) 김옥경(Ok Kyung Kim) 정춘식(Chun Sik Jung) 김주선(Ju Sun Kim)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 512~517쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

Antihyperlipidemic effect of taurine was investigated in the hyperlipidemic rats induced by feeding a diet supplemented with cholesterol (1.5% in diet), vitamin D2(1.25 million IU/kg of diet) and cholic acid (0.5% in diet). The rats were fed the diet containing 1% and 3% of taurine for 8 weeks. The contents of the cholesterol and triglycerides in the serum and liver of the hyperlipidemic rats were increased as compared with those of the control group. Feeding taurine resulted in decreases in total cholesterol and triglyceride levels. The HDL-cholesterol level in serum was decreased in the hyperlipidemic rats, but by administration of taurine its level was increased. In the aorta of the animals, total cholesterol and triglycerides contents were reduced significantly by treatment with taurine. The contents of calcium in the heart of hyperlipidemic rats were greatly increased as compared with those of the control group. Treatment of taurine produced significant decreases in calcium contents in the heart muscle of the animals. These results showed that the hyperlipidemic states in this model of rats were reversed by treatment of taurine.

키워드

Taurine total cholesterol triglyceride HDL-cholesterol vitamin D2 calcium antihy-perlipidemic effect.