항류우머티즘 물질인 p-(아세틸아미노)페닐아세트산의 합성

• 영문명: Synthesis of p-(Acetylamino)phenylacetic acid As an Antirheumatic Agent
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 손병화(Byung Wha Son)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 480~483쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

The efficient synthesis of p-(acetylamino)phenylacetic acid(7), a antirheumatic agent, is reported. Methyl phenylacetate(3) was prepared from Friedel- Crafts reaction of benzene with methyl alpha-chloro-alpha-(methylthio)acetate(1) followed by reductive desulfurization with zinc dust in acetic acid. Compound(7) was obtained from 3 by a sequence of nitration, reduction, N-acylation, and hydrolysis.

키워드

p-(Acetylamino)phenylacetic acid antirheumatic agent Friedel-Crafts reaction methyl otchloro-α-(methylthio)acetate reductive desulfurization.