미성숙 랫트와 젊은 성체 랫트간의 생체내 에탄올 대사의 차이

• 영문명: A Difference in Ethanol Metabolism Between Premature and Young Adult Rats
• 발행기관: 대한약학회
• 저자명: 김성연(Sung Yeon Kim) 김상겸(Sang Kyum Kim) 손영란(Young Ran Son) 김영철(Young Chul Kim)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 492~497쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

A difference in ethanol metabolism between premature and young adult rats was examined. Female SD rats, either 4wk or 12wk old, were injected with a single dose of ethanol (1.5g/kg) through jugular vein and the blood ethanol level was monitored for 300 min using a gas chromatographic method. Reduction of blood ethanol level per unit of time was less and the area under the blood concentration-time curve (AUC) was significantly greater in young adults compared to premature rats. Activity of hepatic alcohol dehydrogenase was not influenced by the age increase. Total cytochrome P-450, cytochrome b5. or aminopyrine N-demethylation was not different between premature rats and young adult rats. However, p-nitrophenol hydroxylation and p-nitroanisole 0-demethylation activities were significantly higher in premature rats. The relative liver weight was 45% greater in premature rats leading to an overall increase in ethanol metabolizing activity in these animals. The results indicate that the reduction in ethanol elimination in young adult rats appears to be mostly associated with the decrease in relative liver weight as the age of animals increases.

키워드

premature rats young adult rats ethanol alcohol dehydrogenase cytochrome P-450 2E1 age difference p-nitrophenol hydroxylation p-nitroanisole O-demethylation relative liver weight.