곰팡이 분리주 No. 51005로부터 포스포리파제 C 저해물질 앙길로스포랄의 분리

• 영문명: Isolation of Anguillosporal, a Potent Inhibitor of Phospholipase C from Fungi Isolate No. 51005
• 발행기관: 대한약학회
• 저자명: 오원근(Won Keun Oh) 이현선(Hyun Sun Lee) 안순철(Soon Cheol Ahn) 고학룡(Hack Ryong Ko) 김보연(Bo Yeon Kim) 민태익(Tae Ick Mheen) 안종석(Jong Seog Ahn)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 433~438쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

MT 51005 as a potent inhibitor of phospholipase C(PLC) was purified from the culture broth of a fungal strain No. 51005 isolated from soil. It was identified as a benzaldehyde derivative, anguillosporal. by the physico-chemical properties and spectroscopic data. Anguillosporal showed the inhibitory activity against purified PLC with an IC50 of 13mcg/ml. And it also inhibited the formation of inositol phosphates(IPt) in platelet-derived growth factor(PDGF)-stimulated NIH3T3gamma1 cells with an IC50 of 0.8mcg/ml.

키워드

phospholipase C inositol phosphates formation anguillosporal.