마크로라이드-포스포트란스페라제 K의 기질 특이성

• 영문명: Substrate Specificity of the Macrolide-Phosphotransferase K
• 발행기관: 대한약학회
• 저자명: 김숙경(Sook Kyung Kim) 오태권(Tae Gwon Oh) 백문창(Moon Chang Baek) 김병각(Byong Kak Kim) 최응칠(Eung Chil Choi)
• 간행물 정보: 『약학회지』제41권 제4호 (1997년), 530~532쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

The MICs of various macrolide, lincosamide and streptogramin B antibiotics against highly erythromycin-resistant Escherichia coli 209K strain were evaluated. E. coli 209K showed high MICs against 14-membered macrolides and the relatively weaker resistance to 16-membered macrolides, lincosamides and streptogramin B. The macrolide-phosphotransferase K from E. coli 209K showed greater substrate specificity to the 14-membered macrolide antibiotics than to the 16-membered macrolide antibiotics, lincosamide and streptogramin B. Therefore, it was considered that the high resistance was due to the macrolide-phosphotransferase K.

키워드

E. coli 209K MIC macrolide-phosphotransferase K substrate specificity.