글루타메이트에 의한 신경독성에 미치는 징코라이드의 영향

• 영문명: Ginkgolides Attenuate Glutamate-Induced Neurotoxicity in Primary Cultures of Rat Cortical Cells
• 발행기관: 대한약학회
• 저자명: 김소라(So Ra Kim) 전미희(Mee Hee Jeon) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 720~726쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by diterpene constituents of Ginkgo biloba leaves, ginkgolides A, B and C. At the concentration of 100nM, ginkgolides up-regulated the activity of glutathione reductase in primary cultures of rat cortical cells exposed to 100mcM glutamate. Furthermore, ginkgolides increased the content of reduced glutathione in glutamate-treated cortical cells. However, ginkgolides showed little effect in reducing superoxide dismutase activity. Ginkgolides did, however, markedly block the production of malondialdehyde, a byproduct of lipid peroxidation in glutamate-treated rat cortical cells.

키워드

glutamate primary cultures of rat cortical cells ginkgolides glutathione reductase superoxide dismutase glutathione malondialdehyde.