F9 기형암종 세포에 대한 해양천연물질의 분화 유도 작용

• 영문명: Differentiation Effect of Marine Natural Compounds on F9 Teratocarcinoma Stem Cells
• 발행기관: 대한약학회
• 저자명: 김리라(Li La Kim) 백진현(Jin Hyen Baek) 조용진(Yong Jin Cho) 손병화(Byung Wha Son) 최홍대(Hong Dae Choi) 김규원(Kyu Won Kim)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 690~696쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

It has been known that many kinds of cancer are caused by continued proliferation or abnormal differentiation. Thus, recent approaches to anticancer therapy have been focused on developing drugs that induce differentiation of cancer cells to normal cells. A typical differentiation agent, all trans-retinoic acid, is unsuitable for anticancer drug because all trans-retinoic acid produces unfavorable side effects and cytotoxicity in normal cells. Therefore, we have screened some new differentiation-inducing compounds obtained from marine organisms using F9 teratocarcinoma stem cells as a model system. We observed that fatty acid. glycolipid, saponin, sphingosine and sterol compounds of marine organisms had differentiation-inducing activity in F9 cells, were determined by morphological changes and Northern blot analysis. The expression of differentiation marker genes, such as laminin B1, type IV collagen and retinoic acid receptor beta were induced by treatment with those compounds.

키워드

differentiation F9 teratocarcinoma stem cell marine natural compounds.