메틸 2-클로로-2-(메틸티오)아세트산을 이용한 치환페놀류로부터 2(3H)-벤조푸란온 유도체의 합성

• 영문명: Synthesis of 2(3H)-Benzofuranone Derivatives from Substituted Phenols Using Methyl 2-chloro-2-(methylthio)acetate
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 김미헌(Mi Heun Kim) 신상훈(Sang Hoon Shin) 손병화(Byung Wha Son)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 640~645쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

5-Alkyl-2(3H)-benzofuranones(3a-e) were prepared from Friedel-Crafts reaction of 4-alkylphenols with methyl 2-chloro-2-(methylthio)acetae(1) followed by the treatment of zinc dust-acetic acid. The reaction of disubstituted phenols with 1 in the presence of stannic chloride afforded 3-methyltWa-2(3H)-benzofuranone derivatives(11a-c), which were readily converted into 2(3H)-benzofuranone derivatives(12a-c) by desulfurization with zinc dust-acetic acid.

키워드

5-Alky1-2(3H)-benzofuranones Friedel-Crafts reaction Methyl 2-chloro-2-(methylthio)acetate Stannic chloride Zinc dust-acetic acid 3-Methylthio-2{3H)-benzofuranone derivatives Desulfurization.