페놀베타인 유도체합성: 프로토베르베린에서 C-환의 관능기도입 및 BC-환의 화학적 변환

• 영문명: Synthesis of Phenolbetaine Derivatives Introduction of Functional Groups to C-ring and Chemical Transformation of BC-ring of Protoberberine
• 발행기관: 대한약학회
• 저자명: 우성주(Seong Ju Woo) 황순호(Soon Ho Hwang) 박예진(Yea Jin Park) 홍유화(You Hwa Hong) 이마세(Ma Se Lee) 김인종(In Jong Kim) 김신규(Sin Kyu Kim)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 621~624쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

Betaine was treated with hydrochloric acid and then with sodium borohydride to give a hydroxy compound 2. The reaction of 2 with thionyl chloride followed by thiourea led a compound 5. Oxidation of compound 2 with pyridinium dichromate(PDC) and succesive treatment with Lawesson''s reagent also afforded the same compound 5. Cleavage of N-C14 bond compound of 7 was carried out via two reaction sequence from the compound 4. Finally, compound 10 was sythesized by a series of transformations from the compound 4.

키워드

Phenolbetaine Pyridinium dichromate Lawesson's Reagent Allocryptopine.