유제놀에 의한 즉시형 알레르기 반응의 억제

• 영문명: Inhibition of Immediate Allergic Reaction by Eugenol
• 발행기관: 대한약학회
• 저자명: 김상현(Sang Hyun Kim) 신태용(Tae Yong Shin) 김형룡(Hyung Yong Kim) 이영미(Young Mi Lee) 이은희(Eun Hee Lee) 신보경(Bo Kyoung Shin) 김윤철(Youn Chul Kim) 안년형(Nyeon Hyoung An) 김형민(Hyung Min Kim)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 679~683쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1M/kg, i.p.) at 60 min before and 5, 10 min after the compound 48/80 treatment (8mg/kg, i.p.) were shown the mortality rates as 0, 44.4, and 77.8%, respectively. A 60 min before administered group revealed a significant inhibition of serum histamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritonea] mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

키워드

Eugenol Immediate allergic reaction Histamine Compound 48/80 Peritoneal mast cells.