천연 퀘루세틴이 수종 항생물질의 항균력에 미치는 병용효과

• 영문명: Antimicrobial Activity of Natural Quercetin Alone and in Combination with Some Antibiotics
• 발행기관: 대한약학회
• 저자명: 어성국(Seong Kug Eo) 김영소(Young So Kim) 이종길(Chong Kil Lee) 이도익(Do Ik Lee) 김일혁(Il Hyuk Kim) 한성순(Seong Sun Han)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 653~658쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

As part of our search for less toxic antimicrobial agents from natural resources. rutin was isolated from Sophora japonica and then hydrolyzed to quercetin. Antimicrobial activity of quercetin was tested in vitro against five kinds of gram positive and ten kinds of gram negative bacteria by serial broth dilution method. Among fifteen kinds of bacteria tested, the antimicrobial activity of quercetin was the most potent against Proteus vulgaris showing minimal inhibitory concentration(MIC) of 125mcg/ml. To investigate the effect of antimicrobial combinations of quercetin with four kinds of antibiotics (ampicillin, cefazolin, oxytetracycline and chloramphenicol). the fractional inhibitory concentration index (FICI) was determined by checkerboard assay for each strain. The antimicrobial combinations of quercetin with four kinds of antibiotics resulted in synergism in one instance, additive effect in four instances, but no antagonism was observed.

키워드

quercetin antimicrobial activity serial broth dilution method minimal inhibitory concentration(MIC) antimicrobial combinations fractional inhibitory concentration index(FICI).