N-4-살리실로아미도-2-아미노-6-피페리디노피리미딘 3-옥사이드.철(III)착체의 물성 및 지시약적 응용성

• 영문명: Properties and Application as the Indicator of N-4-Salicyloamido-2-Amino-6-Piperidinopyrimidine 3-Oxide Fe(III) Complex
• 발행기관: 대한약학회
• 저자명: 이종필(Jong Pill Lee) 신준수(Joon Su Shin) 김경순(Kyoung Soon Kim) 홍선표(Seon Pyo Hong)김경호(Kyeong Ho Kim) 김박광(Bak Kwang Kim)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 670~678쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

The combinations of N-4-salicyloamido-2-amino-6-piperidinopyrimidine 3-oxide (Salmi) and two transitional metals were colored. Among metals, Fe(III) made a distinct colored complex with Salmi. The mole ratio of Salmi and Fe(III) in the complex was 1:1. This Salmi-Fe(III) complex was recrystallized in Hexane/Acetone(=10/1, v/v) and investigated its physicochemical properties. The color of this complex was changed by pH.; deep violet pink in acids, orange in neutral, and yellow in bases. The range of color change was approximately 0.7 pH unit. Acid-base titration of various acidic or basic drugs using Salmi-Fe(III) complex as an indicator showed good accuracy and reproducibility.

키워드

N-4-saMcyloamido-2-amino-6~piperidinopyrimidine 3-oxide- Fe(Ⅲ) complex synthesis properties indicator.