Acyl CoA 합성효소 억제제를 생산하는 토양균의 분리 및 특성 연구

• 영문명: Isolation and Characterization of Soil Microorganism Producing Acyl CoA Synthetase Inhibitor
• 발행기관: 대한약학회
• 저자명: 김경자(Kyoung Ja Kim) 김태성(Tae Sung Kim)
• 간행물 정보: 『약학회지』제40권 제6호 (1996년), 713~719쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.12.31

영문 초록

Identification of soil microorganism strain B-6. a producer of acyl CoA synthetase inhibitor, based on its morphological, physiological, biochemical and chemotaxonomical characteristics was performed. The strain B-6 was identified as Bacillus subtilis. Ihe acyl CoA synthetase inhibitor produced by this strain was highly achieved in fermentation medium that contained glucose 1.0%, soluble starch 1.0%, NH4Cl 0.3%, oatmeal 1.0%, pharmamedia 1.0%, basic magnesium carbonate 0.5%. pH 7.5 at 30oC for 7 days. The optimal pH and temperature for growth were 9.0 and 30oC, respectively. Butanol extract of culture filterate of strain B-6 in acyl CoA synthetase inhibitor production medium containing corn steep liquor exhibited high acyl CoA synthetase inhibitor activity and antimicrobial activity against C. albicans. But chloroform extract of culture filterate of strain B-6 in medium containing NH4Cl, (NH4)2SO4 or urea instead of corn steep liquor exhibited higher antimicrobial activity against C. albicans than that of butanol extract.

키워드

Acyl CoA synthetase inhibitor Bacillus subtilis.