An Application to Select Tag Loci by Using Hierarchical Structures of DNA Markers

• 발행기관: 한국자료분석학회
• 저자명: Makoto Tomita Koji Kurihara Sungho Moon
• 간행물 정보: 『Journal of The Korean Data Analysis Society (JKDAS)』Vol.13 No.6, 2749~2762쪽, 전체 14쪽
• 주제분류: 자연과학 > 통계학
• 파일형태: PDF
• 발행일자: 2011.12.30

영문 초록

A domain where recombination does not occur often, yet maintained linkage disequilibrium exists on DNA sequence is known as a ‘haplotype block’ or ‘Linkage Disequilibrium (LD) block’. Many methods are available to identify haplotype blocks using disequilibrium parameters, such as the well-known Gabriel’s method on Haploview, and so on. After identifying hyplotype blocks, we can also select tagging SNPs (single nucleotide polymorphisms) for these hyplotype blocks such as Tagger on Haploview, etc. We considered that Echelon analysis can be applied to identify hyplotype block and to select tagging SNPs, and report herein that the comprehensive method can be applied according to our new method using Echelon analysis. Finally we evaluated about the comparison of results between our method and others, using real data.

목차

1. Introduction

2. Echelon analysis

3. Methods applied by Echelon analysis

4. Numerical examples and results

5. Discussion

References

키워드

haplotype block LD block tagging SNPs Echelon analysis