감마선에 조사된 생쥐에 있어서 방사선방어효과 평가를 위한 생물학적 파라메타

• 영문명: Biogical Parameters for Assessing Radioprotective Effects in gamma-irradiated Mice
• 발행기관: 대한약학회
• 저자명: 천기정(Ki Jung Chun) 김봉희(Bong Hee Kim) 이영근(Young Keun Lee) 김진규(Jin Kyn Kim)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 278~284쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

This study deals with the biological changes in mice after gama-irradiation. Four weeks old BALB/c mice were irradiated with 6.5Gy of gamma-ray on the fifth day after oral administration of radioprotectants such as ascorbic acid, tocopherol and cysteine. Control group was irradiated with 6.5Gy without pre-administration of radioprotectors. Blood cells and sperm cells were counted and body, testis and spleen were weighed 3 days after irradiation. And also liver antioxidant activity and range of spleen immune cells were measured. Differences in most biological parameters were not clearly distinguished between experimental groups. However, the relative spleen weight, the relative testis weight and the population size of spleen immune cells such as T helper cells, B cells and macrophages measured by means of FACS showed significant difference between irradiated and radioprotectant administered group. It is concluded that the relative spleen weight, the relative testis weight and the population size of spleen immune cells are easy and useful parameters for assessing the effect of radioprotective substances and for quantifying biological damage of radiation, as well.

키워드

Blood cell FACS immune cell liver antioxidant activity radioprotective effect sperm cell.