Lupane계 Triterpenoid류가 임파구 분열에 미치는 효과

• 영문명: Effcets of Lupane-Triterpenoids on Mitogen-induced Proliferation of Lymphocytes
• 발행기관: 대한약학회
• 저자명: 김영옥(Young Ok Kim) 조대현(Dae Hyun Cho) 정혜주(Hye Joo Chung) 김진호(Jin Ho Kim) 장승엽(Seung Yeup Chang) 육창수(Chang Soo Yook) 양기숙(Ki Sook Yang) 오오진(O Jin Oh)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 208~213쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

The effects of five lupane-triterpenoids from leaves of two Acanthopanax spp., chiisanogenin, chisanoside and 22alpha-hydroxychiisanogenin, acakoreoside A and acantrifoside A on the mitogen-induced proliferation were investigated in vitro. T cell proliferation (TCP) to concanavalin A (Con A) and the B cell proliferation (BCP) to lipopolysaccharide (LPS) were increased by chiisanogenin. TCP to Con A was significantly increased by chiisanoside and acankoreoside A, but not affected by chiisanogenin, 22 alpha-hydroxychiisanogenin and acantrifoside A, BCP to LPS was significantly increased by acankoreoside A and acantrifoside A, and slightly increased by chiisanoside, chiisanogenin and 22 alpha-hydroxychiisanogenin.

키워드

Mitogenic proliferation lupane-triterpenoids Acanthopanax spp chiisanogenin chiisanoside 22α-hydroxychiisanogeriin acankoreoside A acantrifoside A concanavalin A lipopolysaccharide.