천연물 Polygodial과 Imidazole계 화합물의 병용에 의한 항진균 활성의 증진

• 영문명: Synergistic Effect of Polygodial with Imidazole Drugs on the Antifungal Acitivity
• 발행기관: 대한약학회
• 저자명: 이상화(Sang Hwa Lee) 이재란(Jae Ran Lee) 김창진(Chang Jin Kim)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 221~227쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

The fungistatic and the fungicidal activities of amphotericin B, fluconazole, miconazole, econazole, and 5-fluorocytosine against Saccharomyces cerevisiae were estimated in the presence of 1/2 minimum inhibitory concentration (MIC) and 1/2 minimum fungicidal concentration (MFC) of polygodial, respectively. Among them, the antifungal activities of miconazole and econazole were greatly (32-128 fold) enhanced by polygodial. The potentiated activity of the imidazoles by polygodial was still shown against several yeast-like fungi including Candida albicans, Candida utilis, and Cryptococcus neoformans, except for Candida krusei. The combination of polygodial with imidazole drugs against Saccharomyces cerevisiae was further examined using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between polygodial and miconazole were 0.16 and 0.19, while the combination of polygodial with econazole exhibited the FIC index of 0.19 and the FFC of 0.25, respectively. These results suggest that polygodial and the imidazoles on the fungistatic and fungicidal action are highly synergistic.

키워드

Polygodial econazole miconazole synergistic.