신원방우황청심원의 심혈관계에 관한 약효

• 영문명: Pharmacological Acitions of New Wonbang Woohwangchungsimwon Pill on Cardiovasculsr System
• 발행기관: 대한약학회
• 저자명: 조태순(Tai Soon Cho) 이선미(Sun Mee Lee) 김낙두(Nak Doo Kim) 허인회(In Hoi Huh) 안형수(Hyung Soo Ann) 권광일(Kwang Il Kwon) 박석기(Seok Ki Park) 심상호(Sang Ho Shim) 신대희(Dae Hee Shin) 박대규(Dai Kyu Park)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 237~250쪽, 전체 14쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (NSCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10-6M) regardless to endothelium contaning or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not affect singficantly the relaxing effects of NSCH and SCH. NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA), Vmax and resting membrane potential (RMT) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a signficant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

키워드

New Wonbang Woohwangchungsimwon Pill Wonbang Woohwangchungsimwon Pill cardiovascular system SHR negative inotropic effect action potential.