신원방우황청심원의 뇌허혈 및 중추신경계에 미치는 영향

• 영문명: Pharmacological Action of New Wonbang Woohwangchungsimwon Pill on Cerebral Ischemia and Central Nervous System
• 발행기관: 대한약학회
• 저자명: 조태순(Tai Soon Cho) 이선미(Sun Mee Lee) 이은방(Eun Bang Lee) 조성익(Sung Ig Cho) 김용기(Yong Kee Kim) 신대희(Dae Hee Shin) 박대규(Dai Kyu Park)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 251~262쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH) and Wonbang Woohwangchungsimwon Pill (SCH), the effects of NSCH and SCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed preventive effects of NSCH and SCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by SCH treatment. In contrast to what was seen with ATP, lipid peroxide were elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NSCH and SCH treatments. While NSCH and SCH had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and strychnine. NSCH and SCH showed sedative effect in rotarod and spontaneous activity test. Furthermore, NSCH and SCH showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCH on cerebral ischemia and central nervous system are similar to those of SCH.

키워드

New wonbang woohwangchungsimwon pill wonbang woohwangchungsimwon pill cerebral ischemia central nervous system.