백강잠의 세포독성성분

• 영문명: Cytotoxic Constituents of Bombycis corpus
• 발행기관: 대한약학회
• 저자명: 권학철(Hak Cheol Kwon) 문형인(Hyung In Moon) 최상훈(Sang Hoon Choi) 이정옥(Jung Ock Lee) 조세연(Sae Yun Cho) 정이연(I Yeon Jung) 김선여(Sun Yeou Kim) 이강노(Kang Ro Lee)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 169~172쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

The acivity-guided fractionation on the MeOH extract of Bombycis corpus inoculated by Beauberia bassiana 101A led to the isolation of two steroids, 24-ethylcholest-4-ene-3,6-dione (1) and ergosterol peroxide (2), as active principles. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell fines, A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 with ED50 values ranging from 3.42 to 11.37mcg/ml.

키워드

Bombycis corpus Beauberia bassiana 101A 24-ethylcholest-4-ene-3,6-dione ergosterol peroxide cytotoxicity.