Miconazole과 Amphotericin B의 항진균 활성에 대한 Anethole의 선택적 병용 효과

• 영문명: Selective Combination Effect of Anethole to the Antifungal Activities of Miconazole and Amphotericin B
• 발행기관: 대한약학회
• 저자명: 이상화(Sang Hwa Lee) 김창진(Chang Jin Kim)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 228~232쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

The combination effect of anethole with amphotericin B, fluconazole, miconazole, or 5-fluorocytosine was investigated against Saccharomyces cerevisiae. When combined with 1/2 minimum inhibitory concentration (MIC) or 1/2 minimum fungicidal concentration (MFC) of anethole, the antifungal activities of fluconazole and 5-fluorocytosine were not changed, but the fungistatic and the fungicidal activities of miconazole were increased 64- and 4-fold, respectively. In the case of amphotericin B, the fungistatic activity was increased 2-fold, while the fungicidal activity was decreased 2-fold. The combination effect of anethole with miconazole or amphotericin B was also investigated at the various concentrations using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between anethole and miconazole were 0.28 and 0.50, whereas the combination of anethole with amphotericin B exhibited the FIC index of 8.25 and the FFC of 32.06, respectively. Thus, it is analyzed that the combination of anethole with miconazole or amphotericin B on the antifungal action shows synergism and antagonism, respectively.

키워드

Anethole miconazole amphotericin B synergism antagonism.