폴리비닐알코올 하이드로겔 캅셀을 삽입한 중공좌제로부터 염산프로프라놀롤의 조절 방출

• 영문명: Controlled Release of Propranolol. HCl from Hollow Type Suppositories Inserted Polyvinyl Alcohol Hydrogel Capsule
• 발행기관: 대한약학회
• 저자명: 진선경(Sun Kyoung Jin) 문이렌(Irene Moon) 구영순(Young Soon Ku)
• 간행물 정보: 『약학회지』제43권 제2호 (1999년), 150~159쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.04.27

영문 초록

Hollow type suppositories inserted polyvinyl alcohol (PVA) hydrogel capsule containing propranolol. HCl (PPH) were prepared using different bases, polyethylene glycol (PEG), Witepsol H-15(WH-15) and Witepsol W-35 (WW-35) to improve the controlled release of PPH. The release of PPH from the hollow type suppository inserted PVA hydrogel capsule was retarded than that from PEG, WH-15, or WW-35 hollow type suppositories in rat rectal cavity. When the suppositories were administered to rats, the controlled release of PPH was proved by the plasma concentration-time profiles of PPH. No significant difference (p<0.05) among the three different hollw type suppositories was observed in terms of AUC and MRT of PPH. WH-15 hollow type suppository inserted 12% of PVA hydrogel capsule caused irritation to rat rectal mucosa. However, the WH-15 hollow type suppository inserted PVA hydrogel capsule caused no severe irritation on rectal mucosa. The application of the hollow type suppositories using PVA in sustained rectal delivery of drugs might be feasible.

키워드

Controlled release of PPH hollow type suppositories rectal absorption and irritation.